London: A study In ~ gene Of the two different mouse model A person with liver disease has helped Austrian researchers better understand the liver. scar Develop more effective treatments for diseases.
Scarring, also known as fibrosis, occurs when liver cells are replaced by fibrous tissue. This causes the largest internal organ to harden and become unable to function, leading to liver failure.
To better understand the scarring process, a team from the Medical University of Vienna and the Center for Molecular Medicine (CeMM) examined gene activity in two different mouse models.
Their results, published in the journal iScience, reveal a dynamic molecular process that could aid in the reversal. liver fibrosis.
The team found that “some genes are upregulated during disease progression and downregulated during regression.”
Some showed persistent changes in the regression phase, pointing to the lasting effects of liver damage.
The research team linked genetic information to disease markers to identify genetic drivers of the disease. They discovered four “hub” genes associated with fibrosis, portal pressure, histological data, and blood markers. The “hub” genes could also be developed into clinically relevant biomarkers, the researchers said.
These results were also tested and confirmed in studies with patients with liver disease.
Scarring, also known as fibrosis, occurs when liver cells are replaced by fibrous tissue. This causes the largest internal organ to harden and become unable to function, leading to liver failure.
To better understand the scarring process, a team from the Medical University of Vienna and the Center for Molecular Medicine (CeMM) examined gene activity in two different mouse models.
Their results, published in the journal iScience, reveal a dynamic molecular process that could aid in the reversal. liver fibrosis.
The team found that “some genes are upregulated during disease progression and downregulated during regression.”
Some showed persistent changes in the regression phase, pointing to the lasting effects of liver damage.
The research team linked genetic information to disease markers to identify genetic drivers of the disease. They discovered four “hub” genes associated with fibrosis, portal pressure, histological data, and blood markers. The “hub” genes could also be developed into clinically relevant biomarkers, the researchers said.
These results were also tested and confirmed in studies with patients with liver disease.