Researchers at Seoul National University Bundang Hospital and UNIST have developed a new technology to remove inflammation-causing factors from blood in vitro. This study, led by Professors Jooheon Kang, Jinmyeong Joo, and Jaehyeok Lee, was published in an academic journal. small way. This discovery is expected to bring about groundbreaking changes in the treatment of sepsis.
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The researchers presented a clinically practical magnetic in vitro blood purification device using magnetic nanoparticles (MNPs) encapsulated in red blood cell-derived nanovesicles (RBC-MNV).
A new approach uses superparamagnetic nanoclusters (SPNCs) to quickly and efficiently remove pathogenic and pathogen-related chemicals that cause sepsis. Preclinical investigations conducted in lethally infected bacteremia model pigs with similar physiological characteristics demonstrated the clinical efficacy of the SPNC-based blood purification approach.
Our study highlights a significant reduction of pathogenic agents in both the blood and major organs, as well as an improvement in hemodynamic and hematologic parameters, followed by preservation and restoration of major organ function. In addition, it can effectively remove a wide range of pathogens and inflammatory substances in the blood and major organs without prior diagnosis, leading to groundbreaking treatment effects..
Jooheon Kang, Professor, Department of Biomedical Engineering, Ulsan National Institute of Science and Technology
Sepsis is an abnormal systemic inflammatory response to infection in which the immune system attacks tissues, resulting in inflammation and organ damage. There are no proven pharmaceutical treatment options for sepsis.
Kang's team developed a similar technology in a previous study completed in 2022 using scavenger MNPs encapsulated in blood cell-derived nanovesicles (MNVs).
MNV magnetically destroys a wide range of pathogens in an in vitro circuit. However, the technology presented in previous studies showed technical limitations due to low susceptibility, making it difficult to purify several liters of extracorporeal blood.
To address this, the researchers in this study performed theoretical calculations to calculate the size and dispersion of MNPs needed to purify an adult patient's blood within one hour. By developing a new hydrothermal synthesis technique, scientists produced SPNCs with improved magnetization rates and particle uniformity.
The therapeutic efficacy of the SPNC-based blood purification approach was further verified using fatally infected bacteremia model pigs. Additionally, in a porcine sepsis model, the in vitro device rapidly collected and magnetically separated a wide range of pathogens at high blood flow rates (>6 L·h).-One).
“Our findings demonstrate that the RBC-SPNC-based blood purification method improves hemodynamics, attenuates inflammatory cytokine responses, maintains organ function, and increases survival. Therefore, we believe that this treatment may be beneficial regardless of the antibiotic initially used to treat sepsis.“The research team pointed out.
Professor Kang outlined plans to verify and introduce medical devices that will promote the use of this technology in the medical field.
As part of our health security strategy, we aim to develop new approaches for the treatment of infectious diseases to combat new mutant pathogens without the need for prior diagnosis. Our findings suggest that RBC-SPNCs can be used for in vitro treatment of severe sepsis in large animals and potentially humans..
Jooheon Kang, Professor, Department of Biomedical Engineering, Ulsan National Institute of Science and Technology
The first authors of this study are Professor Seongjin Park and Suhyun Kim of the Department of Biomedical Engineering at UNIST, and Professor Inwon Park of Seoul National University Bundang Hospital.
This research was conducted with support from the Samsung Research Foundation and the National Research Foundation of Korea (NRF) Basic Research Laboratory (BRL) and the Ministry of Science and ICT (MSIT).
In addition, it received partial funding from the Korea Health Technology Research and Development Project through the Korea Health Industry Development Institute (KHIDI), Korea Dementia Research Center (KDRC), Ministry of Health and Welfare, and POSCO Science Fellowship. TJ Park Foundation.
Journal references:
Jaesoo Park, except. (2023) In vitro blood treatment using functional magnetic nanoclusters alleviates sepsis-induced organ dysfunction in pigs. small way. doi.org/10.1002/smtd.202301428.
Source: https://www.unist.ac.kr/