According to a recently published review by Professor Changyang Gong's research team at Sichuan University Department of Biotherapy, Cancer Center, and State Key Laboratory of Biotherapy, West China Hospital, the rapid development of nanoparticles as delivery systems holds great promise for advancing therapeutic approaches such as: You have. Cancer treatment.
The study results were published in the journal MedComm-Oncology.
Currently, a variety of nanoparticles with unique properties are being created. Some of the nanoparticles used in cancer treatment include micelles, liposomes, polymer nanoparticles, dendrimer nanoparticles, polymersomes, protein nanoparticles, inorganic nanoparticles, exosomes, biomimetic nanoparticles, molecularly imprinted nanoparticles, and hybrid nanoparticles. Here are some examples:
Although cancer is a complex disease, treating it poses various challenges. Fortunately, scientists have created nanoparticles to overcome various obstacles and create complex delivery systems to improve a variety of treatments.
These methods ensure delivery and functionality of the loaded drug. The versatility and modifiability of nanotechnology allows cargo to have long circulation times, targeting capabilities, reactivity to pH, redox, GSH, enzymes, hypoxia, ATP, temperature and ions, as well as to safely transport cargo to its destination underground location. You can protect it.
Cancer treatment has made extensive use of these powerful nanotechnologies. The use of nanoparticles has led to remarkable advances in cancer treatment. Areas of application include combination therapy and monotherapy such as phototherapy, radiotherapy, immunotherapy and gene therapy.
Collaborative nano-CRISPR scaffolds (Nano-CD) are an excellent example. Nano-CD synthesizes GSDME protein by co-delivering cisplatin and CRISPR/dCas9 plasmid by activating the caspase-3 pathway and GSDME expression, which induces significant pyroptosis especially in tumor cells.
Researchers are rapidly gaining a more profound understanding of the obstacles and possibilities presented by various nanoparticles in treating cancer. In this study, recent developments in nanoparticle technology are discussed to overcome these challenges and provide additional innovation possibilities.
Researchers expect that these advances and the continued efforts of researchers in the field will further support nanoparticles' attempts to change the paradigm of cancer treatment and establish nanoparticle-related cancer treatments as standard treatment procedures.
Journal references:
Hwang X., From you. (2024) Advances and applications of nanoparticles in cancer treatment. MedComm – Oncology. doi:10.1002/mog2.67
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